Role of Harmaline in Inhibiting c-Myc, Altering Molecular Typing, and Promoting Apoptosis in Triple-Negative Breast Cancer
Harmaline was found to promote apoptosis and inhibit cell proliferation, invasion, and migration in TNBC cells by targeting the inhibition of c-Myc. It also induced the re-expression of the ER, PR, and HER-2 genes, as well as the ER and PR proteins.
Authors
- Haoyi Xu (ORCID: https://orcid.org/0000-0002-6805-8562)
- Xinyu Song (ORCID: https://orcid.org/0000-0002-3861-1320)
- Y. Liu (ORCID: https://orcid.org/0009-0007-6120-8023)
- Huiling Li (ORCID: https://orcid.org/0000-0002-1724-2087)
- Ziqian Zhao
- Yan Kang (ORCID: https://orcid.org/0000-0001-8351-1145)
- Rui Xu (ORCID: https://orcid.org/0000-0002-6209-7608)
- Chao Dong (ORCID: https://orcid.org/0000-0003-2868-5884)
- Hongyi Yuan
- Zuliyaer Mierzhakenmu
- Yan Ma (ORCID: https://orcid.org/0009-0008-0887-1261)
Institutions
- Xinjiang Medical University (CN)
Publication Details
- Journal
- Breast Cancer Targets and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/bctt.s487070
- Citations
- 1
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.55