ApoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles independent of total apoC-III
While apoC-III is positively associated with biomarkers of cardiometabolic risk, the proportions of three apoC-III proteoforms show opposite associations, independent of total apoC-III concentrations. Measuring not only apoC-III but also the proportions of apoC-III proteoforms can provide valuable information since individuals with similar levels of total apoC-III could display opposite lipid profiles depending on the proportion of apoC-III proteoforms.
Authors
- Núria Amigó (ORCID: https://orcid.org/0000-0002-0116-9145)
- Roser Rosales (ORCID: https://orcid.org/0000-0002-9386-7169)
- Enrique Ozcariz
- Yaiza Esteban (ORCID: https://orcid.org/0000-0002-7283-5977)
- Gemma Rojo‐Martínez (ORCID: https://orcid.org/0000-0003-2179-2134)
- Josefa Girona (ORCID: https://orcid.org/0000-0002-6267-8779)
- Pere Rehues (ORCID: https://orcid.org/0000-0002-7093-9115)
- Montse Guardiola (ORCID: https://orcid.org/0000-0002-9696-7384)
- Ana González-Lleó (ORCID: https://orcid.org/0000-0001-8174-501X)
- Josep Ribalta (ORCID: https://orcid.org/0000-0002-8879-4719)
- Helena Banús
- Gemma Gavaldà-Alsina
Institutions
- Universidad de Las Palmas de Gran Canaria (ES)
- AIT Austrian Institute of Technology GmbH (AT)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Departament de Salut (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Hospital Regional Universitario de Málaga (ES)
- Hospital Universitari Sant Joan de Reus (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12933-024-02531-5
- Citations
- 2
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Instituto de Salud Carlos III
- European Regional Development Fund