Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice
In summary, OLTI improves blood glucose and insulin resistance, decreases blood lipid metabolism, reduces inflammation and apoptosis, suppresses oxidative stress through the Nrf2/HO-1 signaling pathway, mitigates pancreatic and liver tissue injury, and enhances pancreatic β-cell insulin secretion, thereby mitigating T2DM symptoms. Moreover, Reg3g could be an important target for OLTI treatment of T2DM.
Authors
- Lei Fang (ORCID: https://orcid.org/0000-0002-4966-2836)
- Yunfei Luo (ORCID: https://orcid.org/0000-0002-6838-5950)
- Jiadian Huang
- J.F. Li
- Jianping Liu (ORCID: https://orcid.org/0000-0002-8789-7206)
- Shuang Liu (ORCID: https://orcid.org/0000-0002-6276-0617)
- Yuying Zhang (ORCID: https://orcid.org/0000-0002-4134-6505)
- Shiqi Yang (ORCID: https://orcid.org/0000-0003-1314-951X)
- Yu Peng (ORCID: https://orcid.org/0000-0002-3315-5581)
- Shaohua Sun
- Haixia Zeng
Institutions
- Nanchang University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Xinyu University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dddt.s485729
- Citations
- 7
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- Nanchang University