Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan’s Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats
The study suggesting VAL's potential therapeutic role in managing DASA-induced cardiac toxicity. The combination of VAL with DASA not only improved survival rates and reduced cardiac biomarker levels but also preserved myocardial architecture and normalized metabolic profiles. These findings highlight the importance of integrated approaches in evaluating drug efficacy and suggest VAL as a promising candidate for protecting cardiac function in preclinical models of DASA therapy.
Authors
- Abdullah S. Alhamed (ORCID: https://orcid.org/0000-0001-8933-3490)
- Syed Rizwan Ahamad (ORCID: https://orcid.org/0000-0002-4519-0069)
- Hussain N. Alhamami (ORCID: https://orcid.org/0009-0005-2990-8324)
- Hanan Mohammed (ORCID: https://orcid.org/0000-0002-2017-7239)
- Mohammed Alqinyah
- Khalid Alhazzani (ORCID: https://orcid.org/0000-0002-1890-1291)
- Homood M. As Sobeai (ORCID: https://orcid.org/0000-0003-3073-3072)
- Mohammad Algahtani (ORCID: https://orcid.org/0000-0002-0398-6712)
- Fawaz F. Alasmari (ORCID: https://orcid.org/0000-0003-2382-5892)
- Khaldoon Aljerian (ORCID: https://orcid.org/0000-0001-6690-3155)
- Ahmed Z. Alanazi (ORCID: https://orcid.org/0000-0002-2937-540X)
- Moureq Rashed Alotaibi (ORCID: https://orcid.org/0000-0001-7013-6147)
- Ali Alhoshani (ORCID: https://orcid.org/0000-0002-3450-283X)
Institutions
- King Saud University (SA)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dddt.s497212
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- King Saud University