Clinical Significance of Nephrogenic Adenoma of the Urinary Bladder: Implications for Differential Diagnosis and Potential for Malignant Transformation

Nephrogenic adenoma of the urinary bladder is a rare, benign lesion associated with prior inflammation or irritation of the urothelium. Although typically benign, nephrogenic adenoma can present diagnostic challenges due to its potential to mimic malignant tumors of the urinary tract. In this report, we present a case of an elderly woman with a history of recurrent urinary tract infections and bladder stone surgery who developed nephrogenic adenoma. The disease was treated with transurethral resection, which was performed twice during careful follow-up for recurrence. Given the occurrence of recurrence, in both cases during follow-up, the histopathological findings of the removed lesions showed that they were the same type of lesion, nephrogenic bladder adenoma. Given the possibility of recurrence and the rare possibility of malignant transformation, long-term follow-up is essential.