Real-Life Data on the Safety of Pasireotide in Acromegaly: Insights from EudraVigilance
Although PAS had the fewest ICSRs and ADRs, and less frequent serious ADRs, it had more reports frequently classified as serious in the "Metabolism and Nutrition Disorders" category (including events such as elevated blood glucose levels or diabetes) and "Endocrine Disorders" category compared to other SRLs and PEG. Furthermore, there was a higher likelihood of reporting hepatobiliary stones with PAS compared to OCT and PEG. This highlights the importance of adequately monitoring glycemic control and the biliary tract through ultrasound at the initiation and during follow-up of PAS therapy. Improved monitoring and reporting of these ADRs could enhance care for patients with acromegaly.
Authors
- Felicia Gabriela Gligor (ORCID: https://orcid.org/0000-0003-3167-9864)
- Andreea Loredana Vonica-Țincu (ORCID: https://orcid.org/0000-0001-6362-4302)
- Claudiu Morgovan (ORCID: https://orcid.org/0000-0003-2730-8729)
- Adina Frum (ORCID: https://orcid.org/0000-0003-4874-0430)
- Stéliana Ghibu (ORCID: https://orcid.org/0000-0003-2247-4613)
- Anca Butucă (ORCID: https://orcid.org/0000-0003-1540-641X)
- Carmen Maximiliana Dobrea (ORCID: https://orcid.org/0000-0002-9913-1750)
- Călin Homorodean (ORCID: https://orcid.org/0000-0003-1278-970X)
- Ioana Rada Popa Ilie (ORCID: https://orcid.org/0000-0002-5281-5004)
Institutions
- Lucian Blaga University of Sibiu (RO)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3390/ph17121631
- Citations
- 5
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.79