Laser Desorption/Ionization on Au@TiO2 Core@Shell Nanostars for Mass Spectrometric Analysis of Small Molecules
The core@shell nanostars composed of star-like Au nanocores with TiO<sub>2</sub> shells (Au@TiO<sub>2</sub> NSs) are synthesized in a one-pot reaction without any reducing or surface-controlling agents. The Au@TiO<sub>2</sub> NSs exhibit strong absorption in the UV region based on the interaction between the Au nanocore and the TiO<sub>2</sub> shell, and this optochemical property leads to the efficient laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS) analysis of small molecules with low background interference and high reproducible mass signals compared with spherical Au nanoparticles (NPs). The limit of detection and dynamic range values of various analytes also improved with Au@TiO<sub>2</sub> NSs compared with those obtained with spherical Au NPs. Our findings successfully demonstrate that Au@TiO<sub>2</sub> NSs are a promising matrix for the LDI-TOF-MS analysis of various small molecules as well as synthetic polymers.
Authors
- Young‐Kwan Kim (ORCID: https://orcid.org/0000-0002-9929-9510)
- Gyeonghye Yim (ORCID: https://orcid.org/0000-0001-8203-894X)
- Hongje Jang (ORCID: https://orcid.org/0000-0003-1420-7021)
- Hak Dong Cho (ORCID: https://orcid.org/0000-0002-3338-9150)
- Jueun Koh
Institutions
- Kwangwoon University (KR)
- Dongguk University (KR)
Publication Details
- Journal
- Nanomaterials
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3390/nano14231946
- Citations
- 4
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- National Research Foundation
- Ministry of Education - Singapore
- Kwangwoon University
- Ministry of Trade, Industry and Energy
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea