50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations
These findings shed light on regional sequence and structural conservation within antibody sequence databases while also highlighting discrepancies stemming from different numbering schemes. These insights yield valuable guidelines for the precise delineation of antibody CDRs and the strategic design of antibody repertoires, with practical implications in developing innovative antibody-based therapeutics and diagnostics.
Authors
- Thomas J. Magliery (ORCID: https://orcid.org/0000-0003-0779-1477)
- Katherine S. Olson (ORCID: https://orcid.org/0009-0006-6120-0438)
- Zirui Zhu (ORCID: https://orcid.org/0000-0003-4008-6518)
Institutions
- The Ohio State University (US)
Publication Details
- Journal
- Antibodies
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3390/antib13040099
- Citations
- 6
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 2.43