Impact of therapeutic doses of prednisolone and other glucocorticoids on insulin secretion from human islets
In vitro, low-dose PRED treatment significantly impacted GSIS. DEX had a more unfavorable impact on GSIS than HC or PRED, indicating that metabolic effects do not align with anti-inflammatory potency.
Authors
- François Pattou (ORCID: https://orcid.org/0000-0001-8388-3766)
- Chiara Saponaro (ORCID: https://orcid.org/0000-0001-7336-7362)
- Anaïs Coddeville
- Ana Acosta-Montalvo (ORCID: https://orcid.org/0000-0003-2888-5456)
- Stéphanie Espiard (ORCID: https://orcid.org/0000-0002-9584-4294)
- Marie‐Christine Vantyghem (ORCID: https://orcid.org/0000-0002-9369-0463)
- Isaline Louvet (ORCID: https://orcid.org/0009-0007-8445-1157)
- Caroline Bonner (ORCID: https://orcid.org/0000-0002-4430-8280)
- Maria Moreno Lopez (ORCID: https://orcid.org/0009-0000-3499-8604)
- Omolara Khadijat Tijani (ORCID: https://orcid.org/0000-0002-1444-3932)
- Julie Kerr-Conte
- Valery Gmry
Institutions
- Inserm (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
Publication Details
- Journal
- Annales d Endocrinologie
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.ando.2024.101676
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Université de Lille
- European Genomic Institute for Diabetes
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Société Francophone du Diabète