Pioneering the future of dentistry: AI-driven 3D bioprinting for next-generation clinical applications

Artificial intelligence (AI) is revolutionizing dentistry by enhancing the analysis of complex medical imaging data, automating the identification of anatomical landmarks, and improving diagnostic accuracy and treatment planning, etc. When combined with three-dimensional (3D) --bioprinting, AI significantly optimizes the design and manufacturing processes, leading to highly precise and functional 3D-printed dental devices. AI-driven 3D bioprinting represents a transformative leap beyond traditional prosthetics, with the potential to create living tissues capable of regenerating oral structures. This technology pushes the boundaries of dental care by facilitating the development of biocompatible materials and complex tissue constructs that seamlessly integrate with interdisciplinary research, spanning advanced materials, future manufacturing techniques, and innovative clinical methodologies. This review examines the cutting-edge advancements in AI-assisted 3D bioprinting, focusing on its roles in tissue engineering, regenerative dentistry, and personalized treatment planning. Although many of these innovations remain in the research phase, they signify the dawn of a new era in dental medicine, where AI-driven bioprinting is poised to make the regeneration of teeth, gums, and bone structures a clinical reality. This paper provides a concise overview of these developments, emphasizing their potential to revolutionize dental practice. AI-driven 3D bioprinting is revolutionizing dentistry by enabling precise, biocompatible, and regenerative solutions for tissue engineering and personalized treatments, redefining dental medicine. • AI-driven 3D bioprinting enhances precision and customization in dental tissue engineering. • Advanced AI algorithms optimize bioink properties and printing parameters for clinical translation. • 3D bioprinting integrates living cells and biomaterials to regenerate teeth and periodontal tissues. • AI models predict material behavior, ensuring improved biocompatibility and functional integration. • This study bridges the gap between AI innovations and practical applications in dentistry.