Ginsenoside Rg1 exerts antidepressant effect by regulating hepatic kynurenine metabolism through promoting the interaction between HNF4α and PGC1α
Our findings reveal a novel mechanism in which ginsenoside Rg1 upregulates KAT2 and KMO through the HNF4α/PGC1α pathway, reducing hepatic Kyn levels and subsequently alleviating depression.
Authors
- Shu‐Man Pan
- Keke Jia
- Qingyu Zhang (ORCID: https://orcid.org/0000-0001-9739-3899)
- Wenyuan Wu
- Yiming Sun (ORCID: https://orcid.org/0000-0001-6401-7600)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Soochow University (CN)
- Suzhou Guangji Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.jgr.2024.12.002
- Citations
- 4
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.63
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China