Role of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical Stimulation
In open fetal surgery defects, myofibroblasts were elongated with collagen fibrils that either degenerated or had polarity. Whilst cells produced substantially higher Cx43 in the fibroblast than in the epithelial layer, they formed plaques, which may prevent migration and delay healing. Mechanical stimulation of preterm AM enhanced matrix repair proteins and the mechanotransduction should be explored to understand how Cx43 contributes to membrane integrity.
Authors
- David L. Becker (ORCID: https://orcid.org/0009-0009-3339-3430)
- Christopher Thrasivoulou (ORCID: https://orcid.org/0000-0001-9425-8624)
- E. Costa (ORCID: https://orcid.org/0000-0003-0792-5439)
- Tina T. Chowdhury (ORCID: https://orcid.org/0000-0003-4167-7782)
- Anna Louise David (ORCID: https://orcid.org/0000-0002-0199-6140)
- Jan A. Deprest (ORCID: https://orcid.org/0000-0002-4920-945X)
Institutions
- Queen Mary University of London (GB)
- Nanyang Technological University (SG)
- University College London (GB)
Publication Details
- Journal
- Prenatal Diagnosis
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/pd.6722
- Citations
- 1
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Institute for Health and Care Research
- University College London
- Rosetrees Trust
- KU Leuven
- University College London Hospitals NHS Foundation Trust