Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium
This study revealed the ROS-dependent AID-mediated mutagenic activity of the ovulatory FF. The results filled up the missing link between ovulation and the initial TP53 mutation and invited a strategy of antioxidation in prevention of HGSC.
Authors
- Dah‐Ching Ding (ORCID: https://orcid.org/0000-0001-5105-068X)
- Tang‐Yuan Chu (ORCID: https://orcid.org/0000-0003-2717-2681)
- Hsuan-Shun Huang
- Kanchana Subramani
- Pao-Chu Chen
Institutions
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Hualien Tzu Chi Medical Center (TW)
- Buddhist Tzu Chi Medical Foundation (US)
Publication Details
- Journal
- Neoplasia
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.neo.2024.101085
- Citations
- 4
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- Ministry of Science and Technology, Taiwan