Genetic coping mechanisms observed in Leishmania tropica, from the Middle East region, enhance the survival of the parasite after drug exposure
In our study, Leishmania tropica had a jump in the nonsynonymous SNP rates at chromosome 23, including the H locus. CNV was observed among isolates exposed to antimonials, especially involving the gene encoding a ferric iron reductase. Several essential genetic coping mechanisms in the cell were enhanced when exposed to antimony, possibly for the survival of the parasite. Our work supports the perspective that Leishmania uses several mechanisms to adapt to environmental changes and drug exposure.
Authors
- Björn Andersson (ORCID: https://orcid.org/0000-0002-4624-0259)
- Hedvig Glans (ORCID: https://orcid.org/0000-0002-7401-2245)
- Gabriel Machado Matos (ORCID: https://orcid.org/0000-0003-3744-2673)
- Tim Downing (ORCID: https://orcid.org/0000-0002-8385-6730)
- Maria Bradley (ORCID: https://orcid.org/0000-0001-7192-5041)
Institutions
- The Pirbright Institute (GB)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Dublin City University (IE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1371/journal.pone.0310821
- Citations
- 3
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Vetenskapsrådet
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council