An organotypic model for investigating drug-radiation responses in the lung
This study demonstrates that residual DNA damage levels following ionizing radiation in lung tissue are comparable between <i>in vivo</i> and <i>ex vivo</i> tissue slices, suggesting that PCLSs serve as a valuable organotypic model for investigating the effects of drug-radiation combinations.
Authors
- Marcus Green (ORCID: https://orcid.org/0000-0002-4561-8256)
- Maryam Alkadhimi
- Yanyan Jiang (ORCID: https://orcid.org/0000-0003-1521-7045)
- Anderson J. Ryan (ORCID: https://orcid.org/0000-0001-6241-7969)
- Anuradha Helen Manne
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- Journal of Biological Methods
- Published
- 2024-11-28
- DOI
- https://doi.org/10.14440/jbm.2025.0080
- Citations
- 1
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- University of Oxford
- Medical Research Council