Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats
Overall, DPDS inhibited ECM production and improved renal pathological changes, which may be related to reducing oxidative stress damage in the kidney and improving intestinal flora imbalance, providing data support for the further development and application of DPDS in DKD.
Authors
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-3999-4183)
- Peng Xie (ORCID: https://orcid.org/0000-0002-4738-393X)
- Maoting Zhou
- Xianghong Hu
- Xing Wang (ORCID: https://orcid.org/0000-0002-2435-6533)
- Dongmei Long
- Yu Wang (ORCID: https://orcid.org/0000-0003-2420-3585)
Institutions
- North Sichuan Medical University (CN)
- Nanchong Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.3389/fphar.2024.1506398
- Citations
- 8
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.26