Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis
Doxorubicin enhances bortezomib-induced cell death in MM by inhibiting aggresome formation and amplifying ER/Golgi stress and apoptosis. This study highlights the potential therapeutic benefits of combining bortezomib with doxorubicin for MM treatment.
Authors
- Wenhui Jiang (ORCID: https://orcid.org/0000-0002-4144-6725)
- Yuting Liao (ORCID: https://orcid.org/0000-0002-6253-6324)
- Tsung‐Ying Yang (ORCID: https://orcid.org/0000-0003-0198-1077)
- Huilin Pan (ORCID: https://orcid.org/0000-0002-4992-1105)
- Chieh‐Lin Jerry Teng (ORCID: https://orcid.org/0000-0001-9744-0368)
- Chang‐Tze Ricky Yu (ORCID: https://orcid.org/0000-0002-4468-6329)
- J. S. Tsai
- Chia-Yun Pan (ORCID: https://orcid.org/0009-0008-3130-8565)
- Jo‐Mei Maureen Chen (ORCID: https://orcid.org/0000-0003-4863-3395)
- Chi-Yin Nina Chiang
Institutions
- National Chung Hsing University (TW)
- Tunghai University (TW)
- National Chi Nan University (TW)
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12967-024-05920-2
- Citations
- 5
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.27
Funders
- National Chi Nan University
- Taichung Veterans General Hospital
- National Science and Technology Council