COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study

Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51-69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO<sub>2</sub> < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.

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Journal
Scientific Reports
Published
2024-12-03
DOI
https://doi.org/10.1038/s41598-024-81099-2
Citations
4
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
1.56

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article

COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study

Julián Torre-Giménez, Carmen Cepeda Franco, Luis Miguel Marín Gómez, José Manuel Sobrino‐Márquez et al.
4 citations
Scientific Reports
SARS-CoV-2 and COVID-19 Research
1.56
article

COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study

Julián Torre-Giménez, Carmen Cepeda Franco, Luis Miguel Marín Gómez, José Manuel Sobrino‐Márquez, J.M. Álamo-Martínez, Rocío Martínez Gallardo, José Miguel Cisneros, Giovanna Russelli, Aritz Gil Ongay, Héctor Pinargote‐Celorio, Márcia Halpern, Matteo Rinaldi, Pedro Camacho, Esperanza Merino, Domenico Marzolla, Álex Gutiérrez-Dalmau, Mario Fernández‐Ruiz, Rocío Álvarez‐Marín, Diego Rangel‐Sousa, Laura Ambra Nicolini, María Luisa Rodríguez-Ferrero, Miguel Ángel Gómez‐Bravo, Javier Sánchez‐Céspedes, Beatrice Tazza, Elisa Cordero, José González‐Costello, Núria Sabé, Mónica Gozalo-Margüello, María Ángeles Marcos, Silvia Jiménez‐Jorge, María Paniagua‐García, Milagros Heras Vicario, Zeno Pasquini, Frederic Cofán, Renato Pascale, Asunción Moreno, Matteo Bassetti, Francisco López‐Medrano, Antonio Grande‐Trillo, Belén Gutiérrez‐Gutiérrez, G. Bernal-Blanco, Sonsoles Salto‐Alejandre, M. Castel, Carmen Fariñas, Maricela Valerio, Román Hernández‐Gallego, Laura Lladó, Edoardo Melilli, Luís Fernando Aranha Camargo, Jordi Colmenero, Elizabeth Balbi, Pilar González-de-la-Aleja, Maddalena Giannella, José María Aguado, Elena García de Vinuesa-Calvo, Natascia Caroccia, Jesús Rodríguez‐Baño, Carmen Infante-Domínguez, Jorge Calderón‐Parra, Zaira R. Palacios‐Baena, Rafael San Juan, Marino Blanes-Julia, Claudia González-Rico, Cecilia Bonazzetti, Silvia Otero-Rodríguez, Ainhoa Fernández‐Yunquera, Antonio Vena, Jerónimo Pachón, C. Bernal Bellido, António Ramos, Marta Bodro, Rosa Blanes-Hernández, Ana Arias, Sabina Herrera, Carlos Ortiz‐Bautista, Julián Torre-Cisneros, Marino Blanes, Elisa Vidal, Marta Puerta Carretero, Luis Fernando Aranha-Camargo, Alessandra Mularoni, Patricia Muñoz, Laura Merino, Manuela Aguilar-Guisado, Natalia Maldonado-Lizarazo, Laura Linares, Alice Toschi, María José Aladren-Regidor, Javier Paul-Ramos, Michela Di Chiara, Francesca Simone, Gema Montilla-Cosano, Blanca Villacorta-Linaza, Kamilla Ferreira de Moraes, Belén Gallego, Francisco Arnaiz de las Revillas-Almajano, Ignacio Fortea Ormaechea
article en
4 citations

Abstract

Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51-69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO<sub>2</sub> < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.

Scientific ReportsVol. 14(1)
Universitat de Miguel Hernández d'Elx (ES), Universidad Complutense de Madrid (ES), Universidad de Cantabria (ES), Hospital Israelita Albert Einstein (BR), Instituto de Salud Carlos III (ES), Bellvitge University Hospital (ES), Hospital General Universitario Gregorio Marañón (ES), Hospital Universitari i Politècnic La Fe (ES), Research Institute Hospital 12 de Octubre (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Hospital Universitario Virgen Macarena (ES), Instituto Maimónides de Investigación Biomédica de Córdoba (ES), Centro de Investigación en Red en Enfermedades Cardiovasculares (ES), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES), Marqués de Valdecilla University Hospital (ES), D’Or Institute for Research and Education (BR), Hospital Universitario Puerta de Hierro Majadahonda (ES), Instituto de Investigación Marqués de Valdecilla (ES), Centro de Investigación Biomédica en Red (ES), Hospital Clínic de Barcelona (ES), Azienda USL di Bologna (IT), Hospital Universitario Reina Sofía (ES), Instituto de Biomedicina de Sevilla (ES), Instituto de Investigación Sanitaria Aragón (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Centro de Implantología Cirugía Oral y Maxilofacial (ES), Ospedale Policlinico San Martino (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Hospital Universitario Virgen del Rocío (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES), Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT), Universitat de Barcelona (ES), Universidad de Sevilla (ES), University of Genoa (IT), University of Bologna (IT)
Universidad de Sevilla, Ministerio de Ciencia, Innovación y Universidades, European Commission, Ministerio de Ciencia e Innovación, Universitat de Barcelona, Università di Bologna, Universidad de Cantabria, Sociedade Beneficente Israelita Brasileira Albert Einstein, Junta de Andalucía, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Servicio Andaluz de Salud, Instituto de Investigación Marqués de Valdecilla, Instituto de Salud Carlos III
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SARS-CoV-2 and COVID-19 Research
1.56
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