Single-cell transcriptome analysis reveals status changes of immune cells in chronic kidney disease
We established a human CKD kidney immune cell atlas and identified SPP1 macrophages as a unique cell type in CKD. The interaction between SPP1 macrophages and damaged cells may serve as a potential therapeutic target for treating CKD in the future.
Authors
- Xinhuan Fan
- Aiqin Mao
- Changzhu Li (ORCID: https://orcid.org/0000-0002-0844-6416)
- Ka Zhang (ORCID: https://orcid.org/0000-0002-3673-6947)
- Hao Kan (ORCID: https://orcid.org/0000-0001-7656-5495)
- Yuxin Zhu (ORCID: https://orcid.org/0009-0006-0542-578X)
- Li Geng (ORCID: https://orcid.org/0000-0001-6221-4846)
Institutions
- Jiangnan University (CN)
- Anhui Medical University (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-12-03
- DOI
- https://doi.org/10.3389/fmed.2024.1434535
- Citations
- 5
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China