Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma
This study introduces a novel approach to (i) comprehensively address the challenges related to the analysis of chemotherapy data, (ii) mitigate the toxicity-treatment-adjustment bias, and (iii) repurpose existing RCT data for retrospective analyses extending beyond the original trials' intended scopes.
Authors
- Marta Fiocco (ORCID: https://orcid.org/0000-0001-5588-0277)
- Marta Spreafico (ORCID: https://orcid.org/0000-0002-7773-9976)
- Francesca Ieva (ORCID: https://orcid.org/0000-0003-0165-1983)
Institutions
- Leiden University (NL)
- Leiden University Medical Center (NL)
- Human Technopole (IT)
- Princess Máxima Center (NL)
- Politecnico di Milano (IT)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12874-024-02416-x
- Citations
- 3
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.13
Funders
- Ministero dell'Università e della Ricerca
- Medical Research Council