Human airway epithelium controls Pseudomonas aeruginosa infection via inducible nitric oxide synthase
Our findings highlight the critical role of epithelial-derived iNOS in host defence against <i>Pseudomonas aeruginosa</i> infection. Furthermore, we describe a human tissue model that accurately mimics the airway epithelium, providing a valuable framework for systemically studying host-pathogen interactions in respiratory infections.
Authors
- Günter Weiß (ORCID: https://orcid.org/0000-0003-0709-2158)
- Manfred Nairz (ORCID: https://orcid.org/0000-0001-9103-7041)
- Stefanie Dichtl (ORCID: https://orcid.org/0000-0002-7657-329X)
- Thomas Sonnweber (ORCID: https://orcid.org/0000-0002-5080-386X)
- Igor Theurl (ORCID: https://orcid.org/0000-0003-3180-4784)
- Philipp Grubwieser (ORCID: https://orcid.org/0000-0001-6233-8910)
- Nina Böck
- Richard Hilbe (ORCID: https://orcid.org/0000-0001-9987-109X)
- Zlatko Trajanoski (ORCID: https://orcid.org/0000-0002-0636-7351)
- Wilfried Posch (ORCID: https://orcid.org/0000-0001-8955-7654)
- Miriam Alisa Govrins (ORCID: https://orcid.org/0000-0002-7441-4383)
- Markus Seifert
- Erika Kvalem Soto
- Patrizia Moser
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- University Hospital Innsbruck (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1508727
- Citations
- 5
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Universität Basel
- Austrian Science Fund
- Medizinische Universität Innsbruck
- Universität Innsbruck
- European Research Council