Identification of Factors to Predict Transition to Schizophrenia in Subjects with Ultra-high Risk for Psychosis: A Protocol for a Multicenter, Longitudinal Study of Sleep Parameters and Cytokine Levels

This is a multicenter, longitudinal cohort study participated by 7 hospitals in Japan. We will recruit 50 UHR people and 30 healthy volunteers as a control group, and measure positive symptom, depressive symptoms, cognitive function, and social function. Blood cytokines levels and sleep indices, as well as actigraphy data will be monitored. After the baseline assessment, clinical symptoms, sleep indices, and cytokine levels will be measured every 12 weeks for 52 weeks. Actigraphy devices will continue to be worn for 52 weeks, while social function will be assessed over 104 weeks. The results of this study are expected to facilitate the development of novel intervention therapies to reduce the risk of psychosis and improve functional outcomes.

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Publication Details

Journal
Clinical Psychopharmacology and Neuroscience
Published
2024-12-03
DOI
https://doi.org/10.9758/cpn.24.1239
Citations
2
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
1.02
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article

Identification of Factors to Predict Transition to Schizophrenia in Subjects with Ultra-high Risk for Psychosis: A Protocol for a Multicenter, Longitudinal Study of Sleep Parameters and Cytokine Levels

Takashi Ohnishi, Taishiro Kishimoto, Yuji Yamada, Kazuo Mishima et al.
2 citations
Clinical Psychopharmacology and Neuroscience
Sleep and related disorders
1.02
article

Identification of Factors to Predict Transition to Schizophrenia in Subjects with Ultra-high Risk for Psychosis: A Protocol for a Multicenter, Longitudinal Study of Sleep Parameters and Cytokine Levels

Takashi Ohnishi, Taishiro Kishimoto, Yuji Yamada, Kazuo Mishima, Motohiro Ozone, Kenji Hashimoto, Tomiki Sumiyoshi, Masafumi Mizuno, Takahiro Nemoto, Hiroaki Tomita, Shingo Kitamura, Michio Suzuki, Kazuyuki Nakagome
article en
2 citations

Abstract

This is a multicenter, longitudinal cohort study participated by 7 hospitals in Japan. We will recruit 50 UHR people and 30 healthy volunteers as a control group, and measure positive symptom, depressive symptoms, cognitive function, and social function. Blood cytokines levels and sleep indices, as well as actigraphy data will be monitored. After the baseline assessment, clinical symptoms, sleep indices, and cytokine levels will be measured every 12 weeks for 52 weeks. Actigraphy devices will continue to be worn for 52 weeks, while social function will be assessed over 104 weeks. The results of this study are expected to facilitate the development of novel intervention therapies to reduce the risk of psychosis and improve functional outcomes.

Clinical Psychopharmacology and NeuroscienceVol. 23(2)
Kurume University (JP), Toho University (JP), Tohoku University (JP), Akita University (JP), Tokyo Metropolitan Matsuzawa Hospital (JP), National Center of Neurology and Psychiatry (JP), National Institute of Mental Health (JP), Center for Forensic Mental Health, Chiba University (JP), University of Toyama (JP), Nara Medical University (JP)
Good health and well-being
Openalex Percentile: Top 20%
Sleep and related disorders
1.02
DOIOpen Access PDFOpenAlex
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