Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns
This study reveals distinctive nAb profiles in AD, DLB, and PD, pinpointing specific immune deficiencies against pathological proteins. These insights into the autoreactive immune system's role in neurodegeneration suggest nAbs as potential markers for vulnerability to protein aggregation, offering new avenues for understanding and possibly diagnosing these conditions.
Authors
- J. Alexander Ross (ORCID: https://orcid.org/0000-0001-9286-2748)
- Susana Aznar (ORCID: https://orcid.org/0000-0001-7940-6246)
- Sára Bech (ORCID: https://orcid.org/0000-0002-3991-5238)
- Lisette Salvesen (ORCID: https://orcid.org/0000-0002-6375-5764)
- Jonas Folke (ORCID: https://orcid.org/0000-0002-0940-3098)
- Richard Dodel (ORCID: https://orcid.org/0000-0003-2044-6299)
- Steen Gregers Hasselbalch (ORCID: https://orcid.org/0000-0003-4750-4911)
- Anja Hviid Simonsen (ORCID: https://orcid.org/0000-0002-5461-162X)
- Anne‐Mette Hejl
- Annemette Løkkegaard (ORCID: https://orcid.org/0000-0002-7543-6031)
- Kristian Winge (ORCID: https://orcid.org/0000-0001-8354-9143)
- Luisa Knecht
- Tomasz Brudek (ORCID: https://orcid.org/0000-0001-5453-1817)
- Gunhild Waldemar
- Katrine Dalsbøl
- Falk Pilchner
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Frederiksberg Hospital (DK)
- Odense University Hospital (DK)
- Bispebjerg Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12974-024-03293-3
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Parkinsonforeningen
- Gentofte Hospital
- Danmarks Frie Forskningsfond
- Rigshospitalet
- Parkinsonfonden