Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment
Considering the great difficulty in establishing AM cell culture lines, these findings suggest that AM may be more sensitive to microenvironment perturbations than CM. In conclusion, dual FGFR/VEGFR inhibition may be a viable therapeutic strategy that targets the unique biology of AM.
Authors
- John Hyngstrom (ORCID: https://orcid.org/0000-0002-4833-3838)
- Emilio Cortes-Sanchez
- Thomas A. Zangle (ORCID: https://orcid.org/0000-0001-5899-3517)
- Tarek E. Moustafa (ORCID: https://orcid.org/0000-0001-5282-8246)
- Allie H. Grossmann (ORCID: https://orcid.org/0000-0002-7665-1403)
- Richard M. White (ORCID: https://orcid.org/0000-0001-9099-9169)
- Nelly M. Cruz (ORCID: https://orcid.org/0000-0002-9040-6957)
- Eric A. Smith (ORCID: https://orcid.org/0000-0002-7510-5603)
- Robert L. Judson‐Torres (ORCID: https://orcid.org/0000-0002-6559-0553)
- Tsz Yin Chan
- R.L. Belote (ORCID: https://orcid.org/0000-0002-3001-0002)
- Tori A. Seasor (ORCID: https://orcid.org/0009-0004-6731-3244)
- Amanda Jiang (ORCID: https://orcid.org/0000-0002-0327-6980)
- Dekker C. Deacon (ORCID: https://orcid.org/0000-0002-4160-5730)
- David H. Lum (ORCID: https://orcid.org/0000-0002-0159-8724)
- Michael Balatico (ORCID: https://orcid.org/0000-0003-2624-7127)
- Hanlin Zeng (ORCID: https://orcid.org/0000-0002-6904-5261)
- Anastasia Prokofyeva
- Shukran Alizada
- Carly Becker (ORCID: https://orcid.org/0009-0006-4318-1720)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Shanghai Jiao Tong University (CN)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Shanghai Ninth People's Hospital (CN)
- Ludwig Cancer Research (GB)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s13046-024-03234-1
- Citations
- 8
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- University of Utah
- Huntsman Cancer Institute
- National Institutes of Health
- National Cancer Institute