Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine
Our findings suggest that metformin attenuates central sensitization in CM by regulating the activation of microglia and NLRP3 inflammasome through the TREM2-SYK pathway.
Authors
- Zhaoming Ge (ORCID: https://orcid.org/0000-0002-1620-7351)
- Zhenzhen Fan (ORCID: https://orcid.org/0000-0002-3769-5286)
- Songtang Sun
- Dandan Su (ORCID: https://orcid.org/0000-0001-9220-5473)
- Zi Chao Li
Institutions
- Zhengzhou University (CN)
- Lanzhou University Second Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12974-024-03313-2
- Citations
- 24
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.25
Funders
- Lanzhou University