Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease
Extracellular vesicles (EVs) of creeping fat (CrF) derived adipose stem cells effectively attenuate chronic mesenteritis and colitis in Crohn's disease (CD). The lymphatic vessels play an important role in disease development of CD and their functions are improved by CrF-EV-miR-132-3p through RASA1/ERK1/2 signaling. MiR-132-3p expression is upregulated in CrF and serum of CD patients, and tightly linked with inflammation and disease activity.
Authors
- Chunqiu Chen
- Peng Du (ORCID: https://orcid.org/0000-0001-9355-0789)
- Mengfan Chen
- Weigang Shu
- Alexandra Bartolomucci (ORCID: https://orcid.org/0000-0002-4312-5394)
- Fangtao Wang
- Xiaolei Wang (ORCID: https://orcid.org/0000-0001-5441-0855)
- Xin Su (ORCID: https://orcid.org/0000-0002-9157-0193)
- Xiaoli Zhu (ORCID: https://orcid.org/0000-0003-1723-4527)
- Yongheng Wang (ORCID: https://orcid.org/0000-0003-4442-0747)
Institutions
- Tongji University (CN)
- XinHua Hospital (CN)
- McGill University Health Centre (CA)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/ctm2.70086
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China