A versatile approach for geometry-based self-assembly of DNA–protein hybrid nanostructures using histone–DNA interactions
We report an enhanced versatility in constructing DNA-protein hybrid nanostructures using histone-DNA complexes (HDs). By leveraging HDs, we demonstrate precise and scalable assembly of DNA origami tiles and a 2D triangular nanostructure. Our results extend the potential applications of DNA nanotechnology from the nanoscale to the microscale without the need for complex pre-designs.
Authors
- Hajar Al‐Zarah (ORCID: https://orcid.org/0000-0002-5755-4210)
- Satoshi Habuchi (ORCID: https://orcid.org/0000-0002-6663-2807)
- Maged F. Serag (ORCID: https://orcid.org/0000-0002-6153-1089)
- Faisal Alkhaldi
Institutions
- King Abdullah University of Science and Technology (SA)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1039/d4cc05253f
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- King Abdullah University of Science and Technology