Real-life reliability of plasma pTau181, Aβ <sub>42</sub> /Aβ <sub>40</sub> , and pTau181/Aβ <sub>42</sub> measured by Lumipulse G600II in predicting cerebrospinal fluid amyloid status
Plasma biomarkers measured by the Lumipulse G600II platform show strong potential in predicting CSF amyloid status and possibly reduces the need for lumbar punctures. These findings support the potential use of plasma assays in the early diagnosis of AD. Anyway, further validations in larger multicenter cohorts are mandatory.
Authors
- Cristiana Atzori
- Mario Coletti Moja (ORCID: https://orcid.org/0000-0002-8452-683X)
- Delfina Ferrandi
- L. Godi
- Alessia Bagatin
- Daniele Imperiale (ORCID: https://orcid.org/0000-0003-0313-8550)
- Andrea Calcagno (ORCID: https://orcid.org/0000-0003-2534-8815)
- Leonardo Lopiano (ORCID: https://orcid.org/0000-0001-9098-387X)
- Mara Rosso
- Marco Alfonso Narduc Capobianco (ORCID: https://orcid.org/0000-0003-2501-2932)
- Marco Bozzali (ORCID: https://orcid.org/0000-0002-0568-2026)
- Innocenzo Rainero (ORCID: https://orcid.org/0000-0001-6074-9628)
- Eugenia Rota (ORCID: https://orcid.org/0000-0003-3154-7634)
- Massimo Bonzanino
- Marco De Mattei (ORCID: https://orcid.org/0009-0007-4204-4641)
- Maria Roberta Bongioanni
- Massimo Barra
- Daniele Pio Angeloro
- Amelia Murgioni
- Valentina Secci
Institutions
- Ospedale degli Infermi (IT)
- Ospedale Amedeo di Savoia (IT)
- Ospedale San Giacomo Apostolo (IT)
- Santissima Trinità (IT)
- Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
- Ospedale Maria Vittoria (IT)
- Ospedale SS. Annunziata (IT)
- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1177/13872877241300315
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39