Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Identifying Disease Risk Factors for Toxicity and Long‐Term Outcomes in a Prospective, Single‐Arm Trial
We observed favorable OS and EFS after AHSCT for patients with SSc, using CY200/ATG, unmanipulated PBSCs, and MMF posttransplant maintenance, which was comparable to trials with CD34+ graft selection. We identified a possible risk factor, pretransplant low eGFR, for adverse outcomes after AHSCT.
Authors
- Vaishali Sanchorawala (ORCID: https://orcid.org/0000-0002-6307-2445)
- Attaphol Pawarode (ORCID: https://orcid.org/0000-0001-6323-9623)
- George E. Georges
- Ted Alan Gooley (ORCID: https://orcid.org/0000-0002-8182-3652)
- Maureen D. Mayes (ORCID: https://orcid.org/0000-0001-5070-2535)
- Suzanne Kafaja
- Keith M. Sullivan (ORCID: https://orcid.org/0000-0002-1379-9216)
- Chitra Hosing (ORCID: https://orcid.org/0000-0003-0409-5556)
- Mark H. Wener (ORCID: https://orcid.org/0000-0002-8304-6957)
- Daniel E. Furst (ORCID: https://orcid.org/0000-0001-7857-2373)
- Matthew Mei (ORCID: https://orcid.org/0000-0002-1109-6955)
- Richard A. Nash (ORCID: https://orcid.org/0009-0005-2683-5182)
- Jason Kolfenbach (ORCID: https://orcid.org/0000-0002-7043-9161)
- Dinesh Khanna (ORCID: https://orcid.org/0000-0003-1412-4453)
- Robert W. Simms (ORCID: https://orcid.org/0000-0002-0101-1807)
- Leona Holmberg (ORCID: https://orcid.org/0000-0002-2803-0469)
- Suiyuan Huang
Institutions
- Dartmouth College (US)
- Boston University (US)
- Northwestern University (US)
- Boston Medical Center (US)
- City Of Hope National Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, Los Angeles (US)
- Duke University (US)
- University of Washington (US)
- University of Michigan (US)
- Fred Hutch Cancer Center (US)
- Colorado Blood Cancer Institute (US)
- Scleroderma Foundation (US)
- University of Houston (US)
- University of Colorado Anschutz Medical Campus (US)
- Seattle University (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1002/art.43072
- Citations
- 4
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- University of Washington
- Comprehensive Cancer Center, City of Hope
- McGovern Medical School
- University of California, Los Angeles