Revisiting the diagnostics of immunopathological conditions

The immune system is one of the main regulatory homeostatic systems in the human body. The immune homeostasis is maintained by numerous versatile mechanisms. Immune system dysfunction leads to various immunopathological conditions. One of the major challenges is identifying immune system diseases and clinical conditions associated with reversible immune system dysfunctions. In the first case, these conditions may be determined as persistent immune dysfunctions; in the second case, as transient ones. Immunopathological conditions are manifested by various immunological symptoms and signs (syndromes) disrupting normal bodily functions as a result of immune system impairment. Accordingly, clinical practice implies the need to detect a particular immunopathological syndrome, determine its characteristics, assess its severity, identify its causes, perform additional laboratory studies and clinical investigations, and establish a specifically immunological diagnosis. However, no general clinical criteria for diagnosing immunopathological conditions are presently available. A discussion is proposed to be held in order to identify and describe the clinical symptoms associated with dysfunctions of various immune system components. This will serve as a valuable reference for practicing physicians who conduct immunoactive therapy.