The progress of mother-to-child transmission of Human Immunodeficiency Virus (HIV) after Dolutegravir (DTG) optimization program: evidence from a multicenter cohort study in Ethiopia
In the studied cohort population, we observed less than 3% MTCT rate at the end of PMTCT care. The findings might suggest the achievement of MTCT elimination at the hospital level. Although the DTG-based regimen demonstrated a lower risk of transmission, other contributing factors, such as late ART initiation, should be urgently addressed. Future research should focus on prospective designs, interventions targeting late ART initiation, and understanding regional disparities to further advance efforts to eliminate MTCT by 2030.
Authors
- Birkneh Tilahun Tadesse (ORCID: https://orcid.org/0000-0003-4005-8605)
- Eyasu Makonnen (ORCID: https://orcid.org/0000-0002-9259-5288)
- Sintayehu Tadesse
- Eleni Aklillu (ORCID: https://orcid.org/0000-0002-9788-0790)
- Biruk Kebede
- Abel Gedefaw (ORCID: https://orcid.org/0000-0002-5541-0088)
- Yifru Berhan (ORCID: https://orcid.org/0000-0002-3779-0718)
- Stefano Vella (ORCID: https://orcid.org/0000-0003-2347-5984)
- Dejene Hailu
- Siraj Hussen (ORCID: https://orcid.org/0000-0002-1193-9377)
Institutions
- Karolinska University Hospital (SE)
- Hawassa University (ET)
- Karolinska Institutet (SE)
- Africa Centres for Disease Control and Prevention (ET)
- St. Paul's Hospital Millennium Medical College (ET)
- Addis Ababa University (ET)
Publication Details
- Journal
- BMC Public Health
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12889-024-20761-w
- Citations
- 5
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- European and Developing Countries Clinical Trials Partnership