BMSCs Downregulate CXCL12 by Secreting Exosomal miR-20a-5p to Promote Macrophage M2 Polarization and Alleviate the Development of Sepsis

This study demonstrated for the first time that BMSCs-exo promoted the polarization of M2 macrophages through the miR-20a-5p/CXCL12 axis, thus alleviating the development of sepsis. These findings provide a new theoretical basis for the targeted treatment of sepsis with exosomes or miR-20a-5p.

Authors

Chao Xie (ORCID: https://orcid.org/0000-0001-6197-2506)
Linghui Guo
Bo Feng (ORCID: https://orcid.org/0000-0002-4018-3257)
Liming Cheng (ORCID: https://orcid.org/0000-0001-6444-5090)
Chunyan Chen (ORCID: https://orcid.org/0000-0002-3943-1516)

Institutions

Kunming Children's Hospital (CN)

Publication Details

Journal: Immunological Investigations
Published: 2024-12-03
DOI: https://doi.org/10.1080/08820139.2024.2434049
Primary Topic: Extracellular vesicles in disease
Type: article
Field-Weighted Citation Impact: 0.00

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article

BMSCs Downregulate CXCL12 by Secreting Exosomal miR-20a-5p to Promote Macrophage M2 Polarization and Alleviate the Development of Sepsis

Chao Xie, Linghui Guo, Bo Feng, Liming Cheng et al.

Dec 3, 2024

Immunological Investigations

Extracellular vesicles in disease

article

BMSCs Downregulate CXCL12 by Secreting Exosomal miR-20a-5p to Promote Macrophage M2 Polarization and Alleviate the Development of Sepsis

Chao Xie, Linghui Guo, Bo Feng, Liming Cheng, Chunyan Chen

December 3, 2024article en

Abstract

This study demonstrated for the first time that BMSCs-exo promoted the polarization of M2 macrophages through the miR-20a-5p/CXCL12 axis, thus alleviating the development of sepsis. These findings provide a new theoretical basis for the targeted treatment of sepsis with exosomes or miR-20a-5p.

Immunological InvestigationsVol. 54(2)

Kunming Children's Hospital (CN)

Zero hunger

Openalex Percentile: Top 80%

Extracellular vesicles in disease

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