Association between DNA methylation predicted growth differentiation factor 15 and mortality: results from NHANES 1999–2002
DNAm-predicted GDF15 independently predicts all-cause and cardiovascular mortality. This association persists across multiple models and stratified subgroups, supporting GDF15's value as a biomarker for mortality risk stratification. Future research should elucidate underlying biological mechanisms and evaluate GDF15's clinical utility in guiding mortality risk reduction interventions.
Authors
- Yun Shen (ORCID: https://orcid.org/0000-0002-9850-122X)
- Honglian Luo
Institutions
- Pennington Biomedical Research Center (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Aging Clinical and Experimental Research
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1007/s40520-024-02896-3
- Citations
- 2
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.94