Susceptibility of calf lung slice cultures to H5N1 influenza virus
<b>ABSTRACT</b>The current outbreak of HPAI H5N1 virus infections in dairy cattle in the USA underscores the need for easily accessible methods to rapidly assess host susceptibility for infection with known and emerging influenza viruses. Here we show that <i>ex vivo</i> lung slice cultures from calves provide a useful method to rapidly screen host susceptibility to a range of influenza A viruses.
Authors
- Mara Sophie Lombardo (ORCID: https://orcid.org/0009-0007-1643-1795)
- Geert van Amerongen (ORCID: https://orcid.org/0000-0002-5469-6029)
- Monica Mirolo (ORCID: https://orcid.org/0000-0002-5809-0729)
- Kate Guilfoyle (ORCID: https://orcid.org/0000-0001-7292-3021)
- Guus F. Rimmelzwaan (ORCID: https://orcid.org/0000-0002-1921-4581)
- Theresa Störk (ORCID: https://orcid.org/0000-0002-0395-274X)
- Guido van der Net
- Martin Ludlow (ORCID: https://orcid.org/0000-0002-0061-1106)
- Albert Osterhaus (ORCID: https://orcid.org/0000-0001-6535-3497)
Institutions
- University of Veterinary Medicine Hannover, Foundation (DE)
- Viroclinics Biosciences (Netherlands) (NL)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1080/22221751.2024.2432368
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Stiftung Tierärztliche Hochschule Hannover