CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells
Our study demonstrates the use of "IF-THEN" SynNotch-gated CAR-T cells targeting CD33 and CD123 in AML reduces off-tumor toxicity. This strategy enhances T-cell phenotype, improves expansion, preserves HSPCs, and mitigates cytokine release syndrome-addressing critical limitations of existing AML CAR-T therapies.
Authors
- Michael A. Pulsipher (ORCID: https://orcid.org/0000-0003-3030-8420)
- Alexandra E. Kovach (ORCID: https://orcid.org/0000-0002-6742-6749)
- Chintan Parekh (ORCID: https://orcid.org/0000-0001-8100-9151)
- Brent Lee Wood (ORCID: https://orcid.org/0000-0001-7414-3969)
- A. Sorana Morrissy (ORCID: https://orcid.org/0000-0001-8526-562X)
- Deepa Bhojwani (ORCID: https://orcid.org/0000-0002-7559-7927)
- Shawn Barman (ORCID: https://orcid.org/0000-0003-0008-2811)
- Varsha Thoppey Manoharan (ORCID: https://orcid.org/0009-0009-6547-2221)
- Jianping Sun
- Yong‐Mi Kim (ORCID: https://orcid.org/0000-0003-3793-6438)
- Samy Jambon (ORCID: https://orcid.org/0000-0001-7236-3239)
- Alan S. Wayne (ORCID: https://orcid.org/0000-0001-9952-459X)
- Xue Rachel Bito
- Sakunthala Muthugounder
- Shahab Asgharzadeh (ORCID: https://orcid.org/0000-0002-0510-3848)
- Babak Moghimi (ORCID: https://orcid.org/0000-0002-5154-832X)
- Armita Shadfar
Institutions
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- University of Calgary (CA)
- Huntsman Cancer Institute (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1158/2643-3230.bcd-23-0258
- Citations
- 13
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.67