Case - Control Study of Blood Samples of Cancerous Brain Tumor Patients by ICP - OES

The blood of the four brain tumor patients and four healthy donors have been analyzed for the selected trace metal such as cadmium, copper, chromium, iron, zinc, nickel and lead by ICP - OES and develop a correlation between these metal in cases and control. The case - control study shows that trace metal like copper, iron and zinc may influence the carcinogenic process while the metals cadmium, nickel and lead are not traceable neither in cases nor in control. The study reveals that the level of the copper and iron are high in the cases than control. The suspected cause is due to these elements promote angiogenesis and metastasis process. The metal chromium is observed in the cases while it was not detected in any sample of controls. The major goal of our study is the development and description of a routine methods for the analysis of human biological samples by ICP - OES because biological samples are limited in the literature or studies are only dealing with a few toxic or essential trace elements and the study shows that the concentration and correlation of these toxic metal support the angiogenesis and metastasis processes.