Glycyrol targets Pneumolysin (PLY) oligomerization to reduce Streptococcus pneumoniae toxicity
We have actually discovered that Glycyrol, a major component of the widely known Chinese herbal medicine <i>Glycyrrhiza uralensis</i> Fisch., interacts with PLY through hydrogen bonds, Van der Waals and solvation to reduce the pore-forming toxicity of PLY and the toxicity of <i>S. pneumoniae</i> invasion, while not affecting the growth of <i>S. pneumoniae</i> and the production of PLY.
Authors
- Yudi Li (ORCID: https://orcid.org/0000-0002-0324-6888)
- Yibo Hu (ORCID: https://orcid.org/0000-0001-6070-0461)
- Yan Xu (ORCID: https://orcid.org/0000-0003-2697-1297)
- Hongji Wu
- Haoji Meng
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.3389/fphar.2024.1478135
- Citations
- 2
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.77