Fragility in cardiovascular randomized controlled trials with primary continuous outcomes (2018–2022) from multi-perspectives assessment: a cross-sectional survey
The findings suggest that changing only a small number of interventions (median of 7) could alter outcome significance. Reporting the fragility index alongside <i>P</i> values is recommended to provide a clearer understanding of statistical findings' robustness.HighlightsThe continuous fragility index (CFI) represents the minimum patient count needed to modify significance by altering their intervention.Among 72 primary continuous outcomes in 64 cardiovascular RCTs, the overall median CFI was 7, with a corresponding CFQ of 0.032.CFI demonstrated moderate to strong correlations with sample size, total dropouts, and patient numbers analyzed.
Authors
- Xiaoqin Zhou (ORCID: https://orcid.org/0000-0003-4375-9159)
- Weiqiang Ruan (ORCID: https://orcid.org/0000-0002-5482-3470)
- Jin Huang (ORCID: https://orcid.org/0000-0001-7160-2314)
- Jing Li (ORCID: https://orcid.org/0000-0003-4636-5294)
- Ting Wang (ORCID: https://orcid.org/0000-0001-7414-5390)
- Liang Du (ORCID: https://orcid.org/0000-0003-1855-9139)
- Guiying Zhang (ORCID: https://orcid.org/0000-0002-6622-3384)
- Huizhen Liu (ORCID: https://orcid.org/0009-0004-7214-4211)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1080/07853890.2024.2427909
- Citations
- 2
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University