Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum
We used 3D background-suppressed pCASL MRI to evaluate CBF across the AD continuum. Putative SVD-sensitive regions in white matter exhibited diagnosis-related CBF changes. AD and/or SVD risk correlated with reduced CBF in AD and/or SVD-related regions. VRFs were associated with more widespread CBF reductions than amyloid positivity. Spatial patterns of hypoperfusion may differentiate AD and VRF-related effects.
Authors
- Shokufeh Sadaghiani (ORCID: https://orcid.org/0000-0002-2529-5859)
- Sudipto Dolui (ORCID: https://orcid.org/0000-0002-9035-3795)
- Pulkit Khandelwal (ORCID: https://orcid.org/0000-0003-1397-3496)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Banafsheh Shakibajahromi (ORCID: https://orcid.org/0000-0001-6026-4823)
- Sharon Xiangwen Xie (ORCID: https://orcid.org/0000-0002-7886-4103)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Mohammad Taghvaei
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Christopher D. Brown (ORCID: https://orcid.org/0000-0002-3785-5008)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1002/alz.14382
- Citations
- 8
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- Alzheimer's Association
- Pennsylvania Department of Health
- National Institutes of Health