Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Predictors of Preeclampsia

Preeclampsia affects 10 million women each year, accounting for 76,000maternal deaths. Since the one and only effective treatment is deliveryof the fetus, it has therefore lead to iatrogenic preterm deliveries andthus causing 500,000 neonatal deaths each year. Preeclampsia also affects neonatal morbidity to a great extent by causing intrauterine growth restriction, oligohydramnios, iatrogenic low birth weight preterm babies,allof which babies require intensive care. In western countries,incidence is2‐7% out of which 0.1% of them progress to develop seizures, known as eclampsia. To study the efficacy of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting preeclampsia at early second trimester. (13‐20 weeks). To study and compare neutrophil to lymphocyte ratio and platelet to lymphocyte ratio measured at 13‐20 weeks (before the development of disease) among normotensive, non‐severe preeclampsia and severe preeclampsia women. Case control study. 300 Neutrophil and lymphocyte levels are measured using automated cellcounter and the corresponding ratios are measured. Allenrolled patientsare regularly followed up in OPD in their second and third trimesters.Patients who developed preeclampsia are taken as CASES. 5ml venoussample is taken for those who developed disease. Out of 300 women, 68women developed preeclampsia (52 non severe and 16 severepreeclampsia respectively) and 232 were normotensive. NLR and PLRhave shown promising results in many studies on early prediction of preeclampsia. These markers are a part of routine antenatal investigation profile, they are very simple, rapid, non‐invasive and easily availablepredictor tool developed so far in the early prediction of the disease