Tau pathway‐based gene analysis on PET identifies <i>CLU</i> and <i>FYN</i> in a Korean cohort
Gene-based analysis identified CLU and FYN as associated with tau deposition on positron emission tomography (PET). CLU rs149413552 and FYN rs57650567 were associated with brain tau deposition. rs149413552 and rs57650567 were associated with structural brain atrophy. CLU rs149413552 was associated with immediate verbal memory. CLU and FYN may play specific roles in tau pathophysiology.
Authors
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Koung Mi Kang (ORCID: https://orcid.org/0000-0001-9643-2008)
- Yun‐Sang Lee
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Jong‐Won Kim (ORCID: https://orcid.org/0000-0002-0708-9242)
- Jong‐Ho Park (ORCID: https://orcid.org/0000-0001-7371-4555)
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-5759-8969)
- Yoon‐Keun Kim (ORCID: https://orcid.org/0000-0001-7610-7654)
- Yen‐Ning Huang
- Shiwei Liu
Institutions
- Seoul National University (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1002/alz.14416
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Foundation for the National Institutes of Health
- Seoul National University
- Ministry of Science and ICT, South Korea
- National Institutes of Health