Prescription versus over-the-counter venotonics: HPLC-DAD and static digestive model simulation comparison
Our experimental results show that the contents of both listed active substances, diosmin and hesperidin, met the declared amounts in all tested medicaments. Digestion simulation showed identical behaviour in prescription and OTC venotonics. The active substances could not be determined in the non-alkalized sample. Digestion did not affect the solubility of the tested drugs.
Authors
- Matyáš Orsák (ORCID: https://orcid.org/0000-0001-9706-2846)
- L Janoušek
- Róbert Novotný (ORCID: https://orcid.org/0000-0002-5876-2951)
- J. Lachman (ORCID: https://orcid.org/0000-0002-2298-2725)
- Jaroslav Hlubocký (ORCID: https://orcid.org/0000-0003-4318-5490)
- Jan Piťha (ORCID: https://orcid.org/0000-0001-9310-0067)
- Barbora Novotná (ORCID: https://orcid.org/0000-0002-8646-0782)
- Kotikova ZORA
Institutions
- Czech University of Life Sciences Prague (CZ)
- Charles University (CZ)
- Medicon (CZ)
- Institute of Clinical and Experimental Medicine (CZ)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- International Angiology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.23736/s0392-9590.24.05291-x
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00