Synthesis and biological evaluation of aryl derivatives of indole-1,3,4-thiadiazole as anticancer agents
A library of aryl substituted indole-1,3,4-thiadiazole derivatives (<b>10a–j</b>) is synthesized. The in vitro anticancer properties of newly developed compounds <b>10a–j</b> were investigated against four human cancer cell lines like MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer) by employing of MTT assay. The obtained IC<sub>50</sub> value was compared with etoposide which was used as positive control. The promising IC<sub>50</sub> values of compounds 11.6 ± 8.54 µM, 3.34 ± 0.152 µM. Among the synthesized compounds, three compounds <b>10a, 10b</b> and <b>10c</b> displayed more cytotoxic activity than positive control.
Authors
- Laxminarayana Eppakayala
- Sreenivas Enaganti
- Sudhakar Reddy Baddam (ORCID: https://orcid.org/0000-0003-4142-6625)
- Sudhakar Kalagara (ORCID: https://orcid.org/0000-0002-2374-9167)
- Anil Damarancha
- Balaraju Vudari
- Srinivas Ganta
Institutions
- The University of Texas at El Paso (US)
- University of Massachusetts Chan Medical School (US)
- Folkwang University of the Arts (DE)
- Avery Dennison (United States) (US)
- Institute of Science and Technology
- Atotech (United States) (US)
Publication Details
- Journal
- Synthetic Communications
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1080/00397911.2024.2431034
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00