Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses
Our study provides strong evidence that a sustained increase in plasma CXCL12 contributes to neuropathic pain through a positive feedback loop that enhances nociceptor plasticity, and suggests that targeting CXCL12/CXCR4 axis in plasma or nociceptive pathways has potential value in regulating pain chronicity.
Authors
- Chun-Lin Mai
- Zhenjia Lin
- Wei Ming (ORCID: https://orcid.org/0000-0002-1229-8786)
- Yanan Xu (ORCID: https://orcid.org/0000-0003-3582-8863)
- Hong Zhang (ORCID: https://orcid.org/0000-0001-6776-9074)
- Q Z Li
- Hui Zhang (ORCID: https://orcid.org/0000-0003-2613-2960)
- Zhi Tan (ORCID: https://orcid.org/0000-0001-9971-9338)
- Yimin Wang (ORCID: https://orcid.org/0000-0003-2515-6602)
- Ying Li (ORCID: https://orcid.org/0000-0003-3683-9695)
- Yang Yu (ORCID: https://orcid.org/0000-0002-5481-5382)
- Yajuan Wang
- Lijun Zhou (ORCID: https://orcid.org/0009-0001-9373-9941)
- Yufan Zheng (ORCID: https://orcid.org/0000-0001-8633-7701)
- Jun Wan (ORCID: https://orcid.org/0000-0001-9286-6562)
- Shi-Ze Leng
- Min Fang (ORCID: https://orcid.org/0000-0002-5278-1430)
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s10194-024-01917-w
- Citations
- 6
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China