Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
High-grade serous ovarian carcinoma is marked by chromosomal instability, which can serve to promote disease progression and allow cancer to evade therapeutic insults. The report highlights the role of claudin-4 in regulating genomic instability and proposes a novel therapeutic approach to exploit claudin-4-mediated regulation.
Authors
- Hannah L. Dimmick (ORCID: https://orcid.org/0000-0003-3323-3591)
- Benjamin G. Bitler (ORCID: https://orcid.org/0000-0002-5809-5271)
- Daniel Núñez-Avellaneda (ORCID: https://orcid.org/0000-0001-8121-1835)
- Julie Lang (ORCID: https://orcid.org/0000-0003-2424-8222)
- Margaret Neville (ORCID: https://orcid.org/0000-0001-8351-5488)
- Kian Behbakht (ORCID: https://orcid.org/0000-0003-4793-9958)
- Kenneth P. Nephew (ORCID: https://orcid.org/0000-0003-2192-1346)
- Elizabeth R. Woodruff (ORCID: https://orcid.org/0000-0003-0237-7453)
- Fabian R. Villagómez (ORCID: https://orcid.org/0000-0002-4510-1329)
- Patricia Webb
Institutions
- Indiana University Health (US)
- Tecnológico Nacional de México (MX)
- Indiana Cancer Consortium (US)
- Indiana University Bloomington (US)
- Secretaría de Ciencia, Humanidades, Tecnología e Innovación (MX)
- University of Colorado Anschutz Medical Campus (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0558
- Citations
- 5
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.24