Mechanochemical kilogram-scale synthesis of <i>rac</i>-ibuprofen:nicotinamide co-crystals using a drum mill
An eco-friendly mechanochemical process for synthesizing rac -ibuprofen:nicotinamide co-crystals using a drum mill at kilogram scale is presented. This method yields 99% pure co-crystals in 90 min with minimal metal contamination.
Authors
- Frederik Winkelmann (ORCID: https://orcid.org/0000-0002-9220-4486)
- Jan‐Hendrik Schöbel (ORCID: https://orcid.org/0000-0002-0966-1628)
- Michael Felderhoff (ORCID: https://orcid.org/0000-0001-9526-3943)
- Joel Bicker
Institutions
- Max-Planck-Institut für Kohlenforschung (DE)
Publication Details
- Journal
- RSC Mechanochemistry
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1039/d4mr00096j
- Citations
- 7
- Primary Topic
- Crystallization and Solubility Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.82
Funders
- BASF
- HORIZON EUROPE Framework Programme