Lysosomal gene ATP6AP1 promotes doxorubicin resistance via up-regulating autophagic flux in breast cancer
Doxorubicin-induced cytotoxicity is associated with autophagy flux in breast cancer. The lysosomal gene ATP6AP1 facilitates autolysosome acidification and contributes to doxorubicin resistance in breast cancer.
Authors
- Shu Zhou (ORCID: https://orcid.org/0000-0002-9138-477X)
- Xueqin Yan
- Zhen Zhu
- Yinjiao Fei (ORCID: https://orcid.org/0000-0003-3354-4082)
- Weilin Xu (ORCID: https://orcid.org/0000-0001-5476-5541)
- Yuxin Song (ORCID: https://orcid.org/0000-0003-3961-7596)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-8243-3031)
- Mingxing Liang
- Lei Li (ORCID: https://orcid.org/0000-0002-7334-6307)
- Di Xu (ORCID: https://orcid.org/0000-0003-0739-0243)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12935-024-03579-9
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province