Genome-wide association analysis of body conformation traits in Chinese Holstein Cattle
A total of 63 SNPs were identified as significantly associated with 17 body conformation traits in Chinese Holstein cattle through both single-trait and multi-trait GWAS analyses. Sixty-six candidate genes were annotated, with 12 genes identified by both methods, such as SLC4A4, GC, NPFFR2, and ADAMTS3, which are involved in pathways such as growth hormone synthesis and secretion, sphingolipid signaling, and dopaminergic synapse pathways. These findings provide potential genetic marker information related to body conformation traits for the breeding of Chinese Holstein cattle.
Authors
- Yi Ma (ORCID: https://orcid.org/0000-0001-7098-8067)
- Li-Li Chen (ORCID: https://orcid.org/0000-0002-9593-8004)
- Yan Chen (ORCID: https://orcid.org/0000-0002-9806-6782)
- Fei Ge (ORCID: https://orcid.org/0000-0002-2319-3904)
- Shuangshuang Li (ORCID: https://orcid.org/0000-0003-2702-1293)
- Yuxin Liu (ORCID: https://orcid.org/0009-0000-6987-8741)
Institutions
- Tianjin Agricultural University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
- Tianjin Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12864-024-11090-8
- Citations
- 4
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 2.20