Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway
This study reveals that CD147 internalization and CD147-G3BP1 complex translocation to lysosomes induce cytoprotective autophagy, reducing chemotherapy sensitivity by suppressing mTOR activity. It is also shown that chemotherapy drugs combined with autophagy inhibitors can improve the therapeutic effect of cancer, providing new insights into potential targeted therapeutic approaches in treating HCC.
Authors
- Meng Lu
- Meirui Qian (ORCID: https://orcid.org/0000-0002-0315-1977)
- Jian‐Li Jiang (ORCID: https://orcid.org/0000-0001-7952-5667)
- Jing Lin (ORCID: https://orcid.org/0000-0002-4405-134X)
- Ziyu Wan (ORCID: https://orcid.org/0009-0007-6269-1328)
- Hengwei Qin (ORCID: https://orcid.org/0000-0003-2218-3920)
- Tianjiao Zhang (ORCID: https://orcid.org/0000-0001-9807-8620)
- Qian He (ORCID: https://orcid.org/0000-0003-4346-9899)
- Ruo Chen (ORCID: https://orcid.org/0009-0008-7671-5180)
- Huijie Zhang (ORCID: https://orcid.org/0009-0004-8007-0953)
- Xue Liang (ORCID: https://orcid.org/0009-0002-8741-2069)
- Wenli Duan
Institutions
- National Medical Products Administration (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12964-024-01956-5
- Citations
- 7
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Fourth Military Medical University