An overview of the life and career of Seymour Reichlin, MD, PhD

This overview, part of a special Festschrift issue celebrating Dr. Seymour Reichlin’s centennial year, honors the remarkable life and enduring scientific legacy of a researcher whose journey has fundamentally shaped our understanding of neuroendocrinology. From his early insights into stress responses during World War II to his groundbreaking work on hypothalamic control of pituitary function, Dr. Reichlin’s research has bridged the gap between brain function and hormonal regulation. His discovery of multiple glucocorticoid receptor isoforms in the placenta and pioneering work on somatostatin exemplify his innovative approach to understanding complex neuroendocrine systems. Beyond his scientific achievements, Dr. Reichlin’s influence as a mentor has touched generations of endocrinologists, with his trainees leading major medical institutions worldwide. Now at 100 years old, he continues to contribute actively to the field, writing books on the neuroendocrinology of Alzheimer’s disease and exploring the biological basis of ecstatic mysticism. This paper traces his journey from a young medical student fascinated by Hans Selye’s work to becoming a foundational figure in modern neuroendocrinology, highlighting how his personal experiences, including his military service and clinical observations, shaped his unique perspective on the interaction between emotional states and physiological responses.